Role of Survivin as a Diagnostic Tool for Oral Squamous Cell Carcinoma

Authors

  • Hoor Maryam Department of oral Pathology, Peshawar Dental College
  • Sabeen Nasir Department of Pathology, Peshawar Medical College
  • Aneela Basheer Department of Pathology, Riphah international college of dentistry
  • Fatima Iqbal Department of oral Pathology, Peshawar Dental College
  • Fiza Shafiq Department of Oral Pathology, Women medical and dental college
  • Amara Hayat Awan Department of Dental Education, Peshawar Medical College

Keywords:

Oral Squamous Cell Carcinoma, Survivin, Immunohistochemistry

Abstract

Introduction: Oral cancer is among the 10 most common malignancies in the world, about 90% of the oral malignant cancers are oral squamous cell carcinomas (OSCC). Survivin is the recently identified inhibitor of apoptosis protein (IAP). It has a dual function both in cell cycle promotion and apoptosis inhibition.

Objectives: To assess the immuno-histochemical expression of Survivin in oral squamous cell carcinoma and normal oral mucosa.

Material and methods: The study consisted of 30 diagnosed cases of OSCC, and 30 cases of normal healthy oral mucosa as a control. Immuno-histochemical expression of Survivin was analyzed.

Results: Survivin showed positive immunoreactivity in all cases of OSCC (100%) but was absent in normal oral mucosa.

Conclusion: Survivin expression was higher in oral squamous cell carcinoma, indicating that it could be used as a diagnostic marker for OSCC.

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Published

2022-02-09

Issue

Volume.19, Issue-3 (Jul-Sep 2021)

Section

Original article

License

Copyright (c) 2022 Hoor Maryam; Sabeen Nasir, Aneela Basheer, Fatima Iqbal, Fiza Shafiq, Amara Hayat Awan

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

Readers may “Share-copy and redistribute the material in any medium or format” and “Adapt-remix, transform, and build upon the material”. The readers must give appropriate credit to the source of the material and indicate if changes were made to the material. Readers may not use the material for commercial purpose. The readers may not apply legal terms or technological measures that legally restrict others from doing anything the license permits.

How to Cite

1.
Maryam H. Role of Survivin as a Diagnostic Tool for Oral Squamous Cell Carcinoma. Int J Pathol [Internet]. 2022 Feb. 9 [cited 2024 Dec. 22];19(3):151-4. Available from: https://jpathology.com/index.php/OJS/article/view/683