Clinical Utility of MMP-9 Expression in Oral Malignant and Premalignant Lesions

Authors

  • Fiza Shafiq Department of Oral Pathology, Peshawar Dental College, Pakistan
  • Abbas Saleem Khan Department of Oral Pathology, Women Medical College, Pakistan
  • Aneela Bashir Department of Oral Pathology, Peshawar Dental College, Pakistan
  • Fatima Tariq Department of Oral Pathology, Rehman College of Dentistry, Pakistan
  • Hoor Maryum Department of Histopathology , Peshawar Medical College, Pakistan
  • Sajjad Ahmad Department of Histopathology , Peshawar Medical College, Pakistan

Keywords:

Oral squamous cell carcinoma, Oral Potentially malignant disorders, Matrix Metalloproteinase-9, Immunohistochemistry

Abstract

Introduction: The main histological form of oral cancer is oral squamous cell carcinoma (OSCC) which predominantly arises from oral potentially malignant lesions. Matrix metalloproteinases-9 (MMP-9) can degrade different elements of the ECM and basement membrane. In the present study, MMP-9 expression was assessed in tissue samples among cases of oral squamous cell carcinoma, oral potentially malignant disorders (OPMDs) and healthy individuals to assess its important role in OSCC and OPMDs.

Objective: This study aims to assess the immunohistochemical expression of MMP-9 in tissue samples of diagnosed cases of oral squamous cell carcinoma, OPMDs, and normal oral mucosa.

Material and Methods: A total of 60 histologically diagnosed cases of OSCC (n=25), OPMDs (n=25), and Healthy individuals (n=10) as control were included. Immunohistochemical staining was performed for all cases. Results were analyzed using SPSS version 20.

Results: Increased expression of MMP-9 was observed in OSCC cases (n=23/25; 92%) as compared to OPMDs and healthy individuals. Statistically, a significant relation was observed while comparing the grade of staining intensity and MMP-9 expression among OSCC cases (p=0.001) and OPMD cases (p= ≤ 0.01).

Conclusion: Increased expression of MMP-9 was observed in OSCC as compared to OPMDs and healthy individuals. Evaluation of MMP-9 could be of clinical importance in OSCC and can be used as a diagnostic marker of OSCC and OPMDs

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Published

2022-02-03

Issue

Volume.19, Issue-2 (Apr-Jun 2021)

Section

Original article

License

Copyright (c) 2022 Fiza Shafiq; Abbas Saleem Khan, Aneela Bashir, Fatima Tariq, Hoor Maryum, Sajjad Ahmad

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

Readers may “Share-copy and redistribute the material in any medium or format” and “Adapt-remix, transform, and build upon the material”. The readers must give appropriate credit to the source of the material and indicate if changes were made to the material. Readers may not use the material for commercial purpose. The readers may not apply legal terms or technological measures that legally restrict others from doing anything the license permits.

How to Cite

1.
Shafiq F. Clinical Utility of MMP-9 Expression in Oral Malignant and Premalignant Lesions. Int J Pathol [Internet]. 2022 Feb. 3 [cited 2024 Apr. 26];19(2):64-70. Available from: https://jpathology.com/index.php/OJS/article/view/669

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