Role of Survivin as a Diagnostic Tool for Oral Squamous Cell Carcinoma

Authors

  • Hoor Maryam Department of oral Pathology, Peshawar Dental College
  • Sabeen Nasir Department of Pathology, Peshawar Medical College
  • Aneela Basheer Department of Pathology, Riphah international college of dentistry
  • Fatima Iqbal Department of oral Pathology, Peshawar Dental College
  • Fiza Shafiq Department of Oral Pathology, Women medical and dental college
  • Amara Hayat Awan Department of Dental Education, Peshawar Medical College

Keywords:

Oral Squamous Cell Carcinoma, Survivin, Immunohistochemistry

Abstract

Introduction: Oral cancer is among the 10 most common malignancies in the world, about 90% of the oral malignant cancers are oral squamous cell carcinomas (OSCC). Survivin is the recently identified inhibitor of apoptosis protein (IAP). It has a dual function both in cell cycle promotion and apoptosis inhibition.

Objectives: To assess the immuno-histochemical expression of Survivin in oral squamous cell carcinoma and normal oral mucosa.

Material and methods: The study consisted of 30 diagnosed cases of OSCC, and 30 cases of normal healthy oral mucosa as a control. Immuno-histochemical expression of Survivin was analyzed.

Results: Survivin showed positive immunoreactivity in all cases of OSCC (100%) but was absent in normal oral mucosa.

Conclusion: Survivin expression was higher in oral squamous cell carcinoma, indicating that it could be used as a diagnostic marker for OSCC.

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Published

2022-02-09

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Section

Original article

How to Cite

1.
Maryam H. Role of Survivin as a Diagnostic Tool for Oral Squamous Cell Carcinoma. Int J Pathol [Internet]. 2022 Feb. 9 [cited 2024 Jun. 14];19(3):151-4. Available from: https://jpathology.com/index.php/OJS/article/view/683