Immunohistochemical Expression of E-Cadherin in Normal Oral Mucosa, Precancerous Lesions and Oral Squamous Cell Carcinoma

Authors

  • Aneela Bashir Shifa College of Dentistry, Islamabad,
  • Abbas Saleem Khan Department of Oral Pathology Peshawar Dental College
  • Sajjad Ahmed Peshawar Medical College, Peshawar,
  • Fiza Shafiq Women Medical College, Abbottabad
  • Hoor Maryam Younas Peshawar Medical College, Peshawar,

Keywords:

E-cadherin, Immunohistochemistry, Oral squamous cell carcinoma, Oral premalignant lesions

Abstract

Oral cancer is a remarkable component of global cancer burden with significant mortality and morbidity. The present study is designed to assess the Immunohistochemical expression of E-cadherin in tissue samples of diagnosed cases of oral squamous cell carcinoma and oral premalignant lesions and normal oral mucosa.

Objective: This study aims to assess the immunohistochemical expression of E-cadherin in tissue samples of diagnosed cases of oral squamous cell carcinoma, OPMLs, and normal oral mucosa

Materials and Methods: Total of 60 cases were selected for this Descriptive cross-sectional study which included histologically diagnosed cases of OSCC (n=23), OPMDs (n=23), and Healthy individuals (n=14) as control. Immunohistochemical staining was performed for all cases. Results were analyzed using SPSS version 20.

Results: Increased expression of E – cadherin expression was found in samples of normal oral mucosa followed by samples of premalignant and malignant cases. E-cadherin expression was reduced in cases of OPMLs and OSCC as compared to normal oral mucosa. Statistically significant relation was observed while comparing the grade of staining intensity and E-cadherin expression among OSCC cases (p=0.001) and OPML cases (p= 0.01).

Conclusion: We concluded that loss of E - cadherin can be used as a tumour marker that could determine the susceptibility of normal and potentially malignant tissues to transform into oral cancers.

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Published

2022-02-09

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Section

Original article

How to Cite

1.
Bashir A. Immunohistochemical Expression of E-Cadherin in Normal Oral Mucosa, Precancerous Lesions and Oral Squamous Cell Carcinoma. Int J Pathol [Internet]. 2022 Feb. 9 [cited 2024 Jun. 14];19(3):135-42. Available from: https://jpathology.com/index.php/OJS/article/view/681

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