Transformation of Polycythemia Vera into Acute Lymphoblastic Leukemia

Authors

  • Zahida Qasim Department of Hematology Pakistan Institute of Medical Sciences (PIMS) Islamabad
  • Lubna Nasim Department of Hematology Pakistan Institute of Medical Sciences (PIMS) Islamabad
  • Roshan Parveen Department of Hematology Pakistan Institute of Medical Sciences (PIMS) Islamabad

Keywords:

Polycythemia vera, Acute lymphoblastic leukemia

Abstract

Transformation of Polycythemia Rubra Vera to acute lymphoblastic leukemia is extremely rare. A case of 22
years old female is reported who developed acute lymphoblastic leukemia 17 years after the initial diagnosis of
Polycythemia Vera {PV]. Analytical Immunocytochemistry confirmed Precursor B cell Acute Lymphoblastic
Leukemia( BALL) with expression of CD13 and showed gated population of 86% and Blast/atypical population
of weak CD45(92%), CD10+19(72%) and HLADR 87%. The rare occurrence of Acute Lymphoblastic Leukemia
(ALL) in patients of Polycythemia Vera (PV) indicates clonal expansion of an abnormal uncommitted plueripotent,
haemopoietic cell which results in polycythemia Vera (PV) disease phenotype

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Published

2018-11-18

Issue

Section

Original article

How to Cite

1.
Qasim Z, Nasim L, Parveen R. Transformation of Polycythemia Vera into Acute Lymphoblastic Leukemia. Int J Pathol [Internet]. 2018 Nov. 18 [cited 2024 Dec. 10];:91-3. Available from: https://jpathology.com/index.php/OJS/article/view/166