Transformation of Polycythemia Vera into Acute Lymphoblastic Leukemia
Keywords:
Polycythemia vera, Acute lymphoblastic leukemiaAbstract
Transformation of Polycythemia Rubra Vera to acute lymphoblastic leukemia is extremely rare. A case of 22
years old female is reported who developed acute lymphoblastic leukemia 17 years after the initial diagnosis of
Polycythemia Vera {PV]. Analytical Immunocytochemistry confirmed Precursor B cell Acute Lymphoblastic
Leukemia( BALL) with expression of CD13 and showed gated population of 86% and Blast/atypical population
of weak CD45(92%), CD10+19(72%) and HLADR 87%. The rare occurrence of Acute Lymphoblastic Leukemia
(ALL) in patients of Polycythemia Vera (PV) indicates clonal expansion of an abnormal uncommitted plueripotent,
haemopoietic cell which results in polycythemia Vera (PV) disease phenotype
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Copyright (c) 2018 Zahida Qasim, Lubna Nasim, Roshan Parveen
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