Haemophilia; Pattern of Clinical Presentation and Disease Severity

Authors

  • Zahida Qasim Department of Pathology, Divisional Headquarter Teaching Hospital Mirpur, Azad Kashmir, Pakistan
  • Lubna Naseem Department of Pathology, Divisional Headquarter Teaching Hospital Mirpur, Azad Kashmir, Pakistan
  • Naghmi Asif Department of Pathology, Pakistan Institute of Medical Sciences, Islamabad
  • Khalid Hassan Department of Pathology, Islamabad Medical and Dental College Islamabad

Keywords:

Haemarthrosis, haemophilia A, haemophilia B, spontaneous bleeding, ankylosis.

Abstract

Objective: To observe pattern of clinical presentation in patients of Hemophilia A and B.
Materials and Methods: Fifty one patients of Haemophilia A and B were evaluated on the basis of Patient`
s demographic data, history (family, medication, past) and parameters like age, clinical features
(pallor, number of joint involved, ankylosis and pain). Blood complete picture, Coagulation screening
tests, bleeding time, PT, APTT, mixing studies and factor assays were documented.
Results: In total of fifty one patients, twenty two (43.13%) had severe degree of disease (<1% factor
concentrate), while 19(37.2%) patients were diagnosed to have moderate degree of disease (factor concentrate
1-5%) and 10 (19.6%) had mild disease (factor concentrate 5-50%). Patients having severe disease
were diagnosed earlier than those having moderate and mild disease, and had frequent episodes
of bleeding in soft tissues, joints, muscles etc.
Conclusion: Pattern of clinical presentation helps to categories the haemophilia patients as having
mild, moderate or severe degree of disease

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Published

2018-11-17

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Section

Original article

How to Cite

1.
Qasim Z, Naseem L, Asif N, Hassan K. Haemophilia; Pattern of Clinical Presentation and Disease Severity. Int J Pathol [Internet]. 2018 Nov. 17 [cited 2024 Jul. 14];:61-3. Available from: https://jpathology.com/index.php/OJS/article/view/141

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