Impact of Demographic Characteristics on the Use of Combined Oral Contraceptives and their Effect on Biochemical Parameters in Females of Reproductive Age

Authors

  • Nabila Sher Department of Biochemistry, Khyber Girls Medical College Peshawar
  • Gulnaz Begum Department of Biochemistry, Khyber Girls Medical College Peshawar
  • Kalsoom Tariq Department of Biochemistry, Khyber Girls Medical College Peshawar
  • Bela Inayat Department of Biochemistry, Khyber Girls Medical College Peshawar
  • Fazal ur Rahman Bangesh Department of Pathology, Khyber Girls Medical College
  • Saima Nadeem Department of Pathology, Khyber Girls Medical College

Keywords:

Combined oral contraceptives (COC), Cholesterol, high density lipoproteins (HDL), low density lipoproteins (LDL), very low density lipoproteins (VLDL), body mass index (BMI)

Abstract

Use of combined oral contraceptives pills by women in Pakistan has recently been increased like other developing countries due to various governments and other private organizations campaigning for its use in order to space the pregnancies

Objectives: To determine the impact of demographic characteristics on use of combined oral contraceptive pills (COCs) and their effect on the biochemical parameters in females of reproductive age.

Materials & Methods: This cross sectional analytical study included 200 women of child bearing age (14-49 years) divided into three age groups (group A; 14-25years, group B; 26-36years, group C;37-49years), 100 of them using COCs were further divided into (6 months users, 1 year users and > 1 year users). Control group comprises of the remaining 100 participants. These groups were compared for the demographic characteristics like maternal age, age at menarche , menstrual cycle length ,age at marriage, age at first delivery, , gravida, time of combined oral contraceptive use and total duration of use and biochemical parameters like fasting blood glucose and lipid profile.

Results: In urban areas, the prevalence was twice more (9.8% vs. 3.9%) than that of rural. Lowest age group of women taking contraceptives was 22.93±0.62 years in A group and the highest age was 41.27±0.432 years in C group. The lowest age and highest age of marriage was seen in A and Control (12.46±0.16 and 20.07±0.87 years).The highest parity was seen in group C: 6.917±0.49 and the parity were decreasing in B and A respectively. A significant increase was seen in cholesterol (p<0.0001), triglycerides (p<0.0001), LDL (p<0.002602), VLDL (p<0.0001) and fasting blood sugar (p-<0.0002) haemoglobin (p<0.04711) & also in BMI, systolic and diastolic BP were significantly increased in the women treated with combined contraceptive pills by (p<0.00041), (p< 0.00071), (p<0.00922) respectively in the females treated with oral contraceptives

Conclusion:  Demographic characteristics do play a role in the use of combined oral contraceptives and thus affect the biochemical parameters in females of reproductive age.

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Published

2022-04-30

Issue

Section

Original article

How to Cite

1.
Sher N. Impact of Demographic Characteristics on the Use of Combined Oral Contraceptives and their Effect on Biochemical Parameters in Females of Reproductive Age. Int J Pathol [Internet]. 2022 Apr. 30 [cited 2024 Jul. 14];20(1):24-9. Available from: https://jpathology.com/index.php/OJS/article/view/713