Estrogen and Progesterone Receptor Expression in Epithelial Ovarian Cancers and Their Correlation with Histologic Subtypes, Grades and Immnuoexpression

  • Kanwal Zahra Department of Pathology, Pakistan Institute of Medical Sciences, Islamabad
  • Ahmareen Khalid Department of Pathology, Pakistan Institute of Medical Sciences, Islamabad
  • Ashok Kumar i Tanwan Department of Pathology, Pakistan Institute of Medical Sciences, Islamabad
Keywords: Estrogen receptor (ER),, Progesterone receptor (PR), Epithelial Ovarian Cancer (EOC),, Ovarian Surface Epithelim (OSE)

Abstract

Context: Ovarian cancer is the most fatal gynecological malignancy and its major burden is shared by Epithelial
Ovarian Cancers (EOC). Total 85% of all ovarian cancers belonged to EOC. Despite knowing the involvement of
Estrogen and Progesterone in their carcinogenesis, complete understanding of how they transform ovarian surface
epithelium (OSE) is still unknown. Their associations with EOC may differ by different subtypes and grades which can
be helpful in determining the hormonal need of each. This knowledge can also be valuable for targeted hormonal
therapies comparable to those already established in carcinoma breast.
Objective: To evaluate Estrogen and Progesterone receptor expression in various histologic subtypes and grades of
Epithelial Ovarian Cancers.

Published
2018-11-21