Acquired Haemophilia due to Factor-VIII Inhibitors Secondary to Bladder Malignancy: A Case Report
Keywords:
Acquired hemophilia A (AHA),, Partial Thromboplastin Time, Factor VIIIAbstract
Acquired hemophilia A (AHA) is a severe bleeding diathesis caused by the appearance of autoantibodies against
coagulation factor VIII (FVIII). Clinical features of inherited and acquired hemophilia are spontaneous as well as
posttraumatic deep muscle-joint and mucosal bleeding. 50% cases of AHA are associated with autoimmune diseases,
malignancies, medications and the postpartum period, but in the rest of the patients development of FVIII autoantibodies is
idiopathic. Unexplained prolonged activated partial thromboplastin time (APTT) without previous history of bleeding should
warrant work up for AHA. AHA secondary to bladder malignancy is rare with only three cases reported till to-date. We
report a case of an elderly male who developed acquired hemophilia secondary to bladder malignancy and presented with a
rare clinical presentation of hemarthrosis.
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Copyright (c) 2018 Shabana Shumail, Dr. Ayesha , Junaid, Kamran Rashid
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