Bone Marrow Fibrosis (BMF): A New Proposal for Grading System
Keywords:
Bone Marrow Fibrosis, Grading System, Fibrous Tissue ContentAbstract
Semi-quantitative evaluation of Bone Marrow Fibrosis (BMF) in trephine biopsies is important in laboratory workup of many
haematological lesions. Various grading systems for the study of patterns and extent of Fibrous Tissue Content (FTC) have
been used previously. In this paper, a new grading system for FTC has been proposed and studied in trephine biopsies of 160
cases of various haematological lesions. BMF was observed in 59% of cases. The grading system applied in this study was
found quite comprehensive, and it was easy to segregate BMF into various grades with the help of this system. Grade 1
fibrosis was the commonest (35.1%), followed by Grade 2 (28.7%), Grade 3 (24.5%) and Grade 4 (11.5%), respectively. Van
Giesen’s trichrome stain was found useful for demonstration of collagen in Grade 4 fibrosis.
Downloads
Published
Issue
Section
License
Readers may “Share-copy and redistribute the material in any medium or format” and “Adapt-remix, transform, and build upon the material”. The readers must give appropriate credit to the source of the material and indicate if changes were made to the material. Readers may not use the material for commercial purpose. The readers may not apply legal terms or technological measures that legally restrict others from doing anything the license permits.
