Glomus tumors in the urinary tract: a rare case and literature review

Authors

  • Katia Ramos Moreira Leite Faculdade de Medicina da Universidade de Sao Paulo
  • Ana Carolina Armiliato Bogoevich Universidade de São Paulo Brazil
  • Ivan Borin Selegatto Universidade Estadual de Campinas Brazil
  • Thiago José Penachim Universidade Estadual de Campinas Brazil
  • Wilmar Azal Neto Universidade Estadual de Campinas Brazil

DOI:

https://doi.org/10.59736/IJP.22.03.891

Keywords:

Glomus tumor, Kidney, Urinary tract, Immunohistochemistry

Abstract

Background: The Glomus tumor is a rare mesenchymal tumor that predominantly affects the subcutaneous skin of the distal extremities. Solid organs are rarely affected, and the urinary tract has been the reason for isolated reports. This paper reviews the occurrence of glomus tumors in the entire urinary tract.

Case Report: We report a case of a 56-year-old female, asymptomatic, with a 5.5 cm renal glomus tumor, and review the literature about the urinary tract involvement by this rare neoplasia.

Conclusion: Glomus tumor mostly behaves as a benign lesion that rarely affects solid organs, being the kidney, the most affected organ in the urinary tract. It should be considered in the differential diagnosis of another renal cell tumor, especially those that are eosinophilic.  

Author Biographies

  • Katia Ramos Moreira Leite, Faculdade de Medicina da Universidade de Sao Paulo

    1Faculdade de Medicina 

    2Laboratório Genoa/LPCM

  • Ana Carolina Armiliato Bogoevich, Universidade de São Paulo Brazil

    Faculdade de Medicina da 

  • Ivan Borin Selegatto, Universidade Estadual de Campinas Brazil

    Universidade Estadual de Campinas 

  • Thiago José Penachim, Universidade Estadual de Campinas Brazil

    Universidade Estadual de Campinas – UNICAMP

  • Wilmar Azal Neto, Universidade Estadual de Campinas Brazil

    Universidade Estadual de Campinas – UNICAMP

References

Weissferdt A, Kalhor N, Moran CA. Intrathoracic glomus tumors and glomangiosarcomas: a clinicopathological and immunohistochemical study of 14 cases with emphasis on anatomic distribution. Virchows Arch. 2016 Nov; 469(5):541-6. Doi: 10.1007/s00428-016-2013-y.

Chalise S, Jha A, Neupane PR. Glomangiomyoma of Uncertain Malignant Potential in the Urinary Bladder: A Case Report. JNMA J Nepal Med Assoc. 2021; 59(239):719-22.

Chen L, Lai B, Su X, Wang J. Unusual glomus tumor of the bladder: a rare case report and literature review. BMC urology. 2021; 21(1):66.

Palmisano F, Gadda F, Spinelli MG, Maggioni M, Rocco B, Montanari E. Symplastic glomus tumor of the urinary bladder treated by robot-assisted partial cystectomy: a case report and literature review. Urologia. 2018;85(3):130-2.

Tripodi SA, Rocca BJ, Mourmouras V, Barbanti G, Colecchia M, Ambrosio MR. Benign glomus tumor of the urinary bladder. Archives of pathology & laboratory medicine. 2013;137(7):1005-8.

Shim HS, Choi YD, Cho NH. Malignant glomus tumor of the urinary bladder. Archives of pathology & laboratory medicine. 2005;129(7):940-2.

Tullie STE, Quraishi MK, Karawita T, Anjarwalla S. Rare presentation of a testicular glomus tumour. BMJ Case Rep. 2019;12(11).

Garg S, al-Talib RK, Harrison GS. Glomus tumour of the testicle. British journal of urology. 1997;80(5):823-4.

Sun Z, Sun F, Yu C, Xiao H, Xu Q, Gao B, et al. Malignant glomus tumor of prostate: A case report. Frontiers in oncology. 2023;13:1121307.

Demir M, Tuncekin A, Yagmur I, Aydogdu A. Malignant Glomus Tumor of the Ureter. J Coll Physicians Surg Pak. 2022; 32(12):SS206-SS8.

Iwamura R, Komatsu K, Kusano M, Kubo C, Inaba Y, Shiba E,et al. PDGFRB and NOTCH3 Mutations are Detectable in a Wider Range of Pericytic Tumors,IncludingMyopericytomas,Angioleiomyomas, Glomus Tumors, and Their Combined Tumors. Mod Pathol. 2023 Mar; 36(3):100070. Doi: 10.1016/j.modpat.2022.100070.

Gupta S, Folpe AL, Torres-Mora J, Reuter VE, Zuckerman JE, Falk N, et al. Immunohistochemical expression of renin and GATA3 help distinguish juxtaglomerular cell tumors from renal glomus tumors. Hum pathol 2022 oct;128:110-23.

Zhao M, Yang M, Gu W, Chen X, Chen H, Kuick CH, et al. Glomus Tumor of the Kidney in a Child With Tuberous Sclerosis. Pediatr Dev Pathol. 2020;23(3):230-4.

Surianarayanan P, Menon AR, Sundersingh S, Raja A. Inoperable Renal Malignant Glomus Tumor, the answers for all the "W's"? J Kidney Cancer VHL. 2024;11(1):33-40.

Kapogiannis F, Tsiampa E. Glomus Tumor of the Kidney Harboring Malignant Potential. Cureus. 2021; 13(11):e19479.

Li R, Petros FG, Davis CJ Jr., Ward JF. Characterization of Glomus Tumors of the Kidney. Clin Genitourin Cancer. 2017 Sep 7:S1558-7673(17)30277-X. doi: 10.1016/j.clgc.2017.09.002.

Almaghrabi A, Almaghrabi N, Al-Maghrabi H. Glomangioma of the Kidney: A Rare Case of Glomus Tumor and Review of the Literature. Case Rep Pathol. 2017; 2017:7423642.

Lu YY, Wang RC, Wang HY. Malignant Glomus Tumor of the Kidney. Am J Med Sci. 2017;353(3):310.

Al-Ahmadie HA, Yilmaz A, Olgac S, Reuter VE. Glomus tumor of the kidney: a report of 3 cases involving renal parenchyma and review of the literature. Am J Surg Pathol. 2007 Apr; 31(4):585-91.

Ai J, Zhang S, Qian Y, Kang L, Zhang L, Zhao J. Radiotherapy and Anrotinib in Malignant Glomus Tumor of the Bladder: A Case Report and Literature Review. Cancer Biother Radiopharm. 2024;39(4):318-21.

Downloads

Published

2024-11-18

Issue

Section

Case Reports

How to Cite

1.
Ramos Moreira Leite K, Bogoevich ACA, Selegatto IB, Penachim TJ, Neto WA. Glomus tumors in the urinary tract: a rare case and literature review. Int J Pathol [Internet]. 2024 Nov. 18 [cited 2024 Dec. 30];22(3):156-61. Available from: https://jpathology.com/index.php/OJS/article/view/891