Measles Vaccine Failure OR Emergence of New Virus strain: 2018 Measles Outbreak Peshawar, Pakistan

Authors

  • Ayesha Khattak Department of Zoology University of Peshawar Khyber Pakhtunkhwa, Pakistan
  • Sanaullah Khan Department of Zoology University of Peshawar Khyber Pakhtunkhwa, Pakistan
  • Shaista Yousaf Department of Zoology University of Peshawar Khyber Pakhtunkhwa, Pakistan
  • Aisha Gul Department of Zoology University of Peshawar Khyber Pakhtunkhwa, Pakistan
  • Faheem Ullah Type C Takhti Nasrati Hospital Karak Khyber Pakhtunkhwa, Pakistan
  • Muhammad Nasir Khabir Department of Zoology University of Peshawar Khyber Pakhtunkhwa, Pakistan
  • Sobia Attaullah Islamia College University Peshawar Khyber Pakhtunkhwa, Pakistan

Keywords:

Measles, Children, Vaccines, Genotypes, Co-infection

Abstract

Introduction: Measles vaccines are included in routine immunization programs started in 19784 but still, a large number of cases have been reported in the recent past across the country

Objective: The frequency and genotypes of measles Virus (MeV) in children vaccinated against Measles Virus (MeV) were investigated through PCR using gene-specific primers during the 2018 measles outbreak in Peshawar, Pakistan.

Methodology: Throat swabs and urine samples, as well as clinical and demographic data, were collected from 156 children with measles-like symptoms, admitted to different tertiary care hospitals in Peshawar.

Results: Most prevalent genotypes found were D3, G2, and B3.1. The distribution of MeV genotypes was statistically significant in unvaccinated children (p<0.005). Mixed genotypes (D3 and D7) were identified in 2.45% of children administered with single or double dose and 14.7% of the samples were not typed viz in Clade-D (7.4%), Clade- B (4.1%), and Clade- G (3.3%). The predominant genotype found in vaccinated and unvaccinated children was D3 followed by B3.1 and G2. Most of the children were found positive for MeV of age 1-5 years and the notable complications were severe pneumonia (5.6%) and diarrhea (26.8%). Furthermore, MeV and Rubella Virus (RV) coinfection was found in 6.4% of the total children, especially in unvaccinated children of the study.

Conclusion: It is concluded that MeV genotype D3 was prevalent in the study population, importantly in the vaccinated children. Moreover, a substantial number of un-typed samples seem the emergence of new variants.

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Published

2023-03-10

Issue

Section

Original article

How to Cite

1.
Khattak A. Measles Vaccine Failure OR Emergence of New Virus strain: 2018 Measles Outbreak Peshawar, Pakistan. Int J Pathol [Internet]. 2023 Mar. 10 [cited 2024 Jun. 14];20(4):182-8. Available from: https://jpathology.com/index.php/OJS/article/view/803