Demographic Factors Influence the Laboratory Parameters in COVID 19 Patients - Experience from Tertiary Care Center in Islamabad

  • Summaya Sohail Department of Pathology, Pakistan Institute of Medical Sciences, Islamabad, Pakistan
  • Sundas Ali Department of Pathology, Pakistan Institute of Medical Sciences, Islamabad, Pakistan
  • Armaghana Qamar Khan Department of Pathology, Pakistan Institute of Medical Sciences, Islamabad, Pakistan
  • Javera Tariq Department of Pathology, Pakistan Institute of Medical Sciences, Islamabad, Pakistan
  • Maha Tariq Department of Pathology, Pakistan Institute of Medical Sciences, Islamabad, Pakistan
  • Sohail Raza Department of Medicine, KRL Hospital, Islamabad
Keywords: COVID-19, Lymphopenia, demographics, Neutrophil to Lymphocyte ratio NLR, MuLBSTA Score system, Immune senescence

Abstract

Background: As the pandemic of COVID-19 spread in different part of world, reports show significant differences in disease presentation, clinical symptoms, and progression, treatment-response and intensive care admissions

Objective: The aim is to study demographic parameters and to evaluate and compare various basic laboratory parameters according to age groups of PCR confirmed COVID-19 patients and statistically analyze its significance.

Material and Methods: It is a cross sectional, prospective study of 3 months duration from April 2020 to 2020, Pakistan Institute of Medical Sciences.

Results: 115 COVID-19 positive patients with moderate to severe symptoms were included in the study.  Patients were divided into three groups based on their ages, less than 25 years, 25-50 years and more than 50 years. Distribution of SARS-CoV-2 patients showed male predominance and age gradient with only few cases in children. We found that laboratory parameters associated with worse prognosis as lymphopenia and hypoalbuminemia were more common in patients more than 50 years of age. Neutrophilia was more common in young patients. Deranged Neutrophil lymphocyte ratio NLR was observed in all three-age stratified groups

Conclusion: Combining parameters as NLR and age can be a potential indicator of prognosis.

Published
2022-10-04