Relationship of High Molecular Weight Adiponectin with Female Breast Cancer

Authors

  • Alia Banori Department of Pathology, Khyber Medical College, Peshawar & IRNUM Hospital, Peshawar
  • Ejaz Hassan Khan Department of Pathology, Northwest School of Medicine, Peshawar
  • Ahmad Rafiq Department of Chemical Pathology, Khyber Medical College Peshawar
  • Mohsin Shafi Department of Pathology, Khyber Medical College Peshawar
  • Sadaf Durrani Department ofBiochemistry Khyber Medical College Peshawar
  • Ambreen Ali Pak International Medical College, Peshawar

Keywords:

Adiponectin, High Molecular Weight Adiponectin, Breast cancer

Abstract

Background: Role of serum adiponectin level is very important in the prediction of cancer. Regarding breast cancer, adiponectin’s role is still under-investigation among women of pre and postmenopausal stage of life.

Objective: To determine serum levels of HMW adiponectin in female patient of breast cancer.

Methods: This is a case control study.This study consisted of 300 female subjects. Among which 150 consisted of patients having breast cancer and 150 consisted of normal healthy females as a control.This study was conducted in IRNUM Hospital Peshawar, Khyber Pakhtunkhwa (KPK). The duration of the study was 12 months i.e. from March 2016 to March 2017. Fasting blood samples were obtained from the participants and were analyzed for serum adiponectin level.

Results: Significantly low adiponectin level was observed in cases than in controls with (P= 0.001). No significant difference was found in blood sugar level among both the groups (P=0.28). Significantly high level of serum insulin was found in patients having breast cancer as compared to control with (P= 0.02).

Conclusion: The current study shows that serum adiponectin level is markedly decreased in breast cancer patients. It shows an inverse relationship with breast cancer, suggesting its protective role in breast cancer.

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Published

2020-06-24

Issue

Volume.17, Issue-4 (Oct-Dec 2019)

Section

Original article

License

Copyright (c) 2020 Alia Banori; Ejaz Hassan Khan, Ahmad Rafiq, Mohsin Shafi, Sadaf Durrani, Ambreen Ali

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

Readers may “Share-copy and redistribute the material in any medium or format” and “Adapt-remix, transform, and build upon the material”. The readers must give appropriate credit to the source of the material and indicate if changes were made to the material. Readers may not use the material for commercial purpose. The readers may not apply legal terms or technological measures that legally restrict others from doing anything the license permits.

How to Cite

1.
Banori A. Relationship of High Molecular Weight Adiponectin with Female Breast Cancer. Int J Pathol [Internet]. 2020 Jun. 24 [cited 2024 Dec. 21];17(4):176-9. Available from: https://jpathology.com/index.php/OJS/article/view/519