Overexpression and prognostic significance of p53 in Basal Cell Carcinoma, Squamous cell Carcinoma and Malignant Melanoma of the Skin

Authors

  • Saira Javeed Department of Pathology, Islam Medical & Dental College, Sialkot, Pakistan
  • Hania Naveed Assistant Professor, Department of Pathology, Shifa College of Medicine - Shifa Tameer-e-Millat University, Islamabad, Pakistan
  • Rabiya Fawad Department of Pathology, Shifa College of Medicine, Islamabad, Pakistan
  • Muhammad Kashif Baig Department of Pathology, Aziz Fatima Medical & Dental College, Faisalabad, Pakistan
  • Ashok Kumar Tanwani 4Department of Pathology, Hazrat Barri Sarkar Medical & Dental College, Islamabad, Pakistan
  • Faiz Ahmed Faiz Department of Pathology, Islam Medical & Dental College, Sialkot, Pakistan

Keywords:

p53 over expression, basal cell carcinoma, squamous cell carcinoma, malignant melanoma, skin

Abstract

Objective: To evaluate the immunohistochemical overexpression of p53 in basal cell carcinoma squamous cell carcinoma, collectively known as non-melanoma skin cancer and malignant melanoma of skin in the local population and determine its prognostic significance. 

Methods: It was a descriptive cross-sectional study conducted in the Pathology Department of Pakistan Institute of Medical Sciences, Islamabad. All skin biopsies received in the pathology department and diagnosed as basal cell carcinoma, squamous cell carcinoma and malignant melanoma were included in the study. 55 skin cancers were included which comprises of 61.8% basal cell carcinoma, 25.5% squamous cell carcinoma and 12.7% malignant melanoma. p53 overexpression was evaluated by immunohistochemistry and the results were analyzed by using SPSS version 21. A p-value <0.05 was considered significant.

Results:  p53 over expression was seen in 82.3% of basal cell carcinoma, 50% of squamous cell carcinoma while none was seen in malignant melanoma. (p value <0.001). 55.8% cases of basal cell carcinoma showed strong staining, 20.5% had moderate staining and 5.8% had weak staining pattern. Squamous cell carcinoma showed strong (57.1%) and moderate (42.8%) staining pattern. A significant correlation between p53 over expression and the tumor size of both basal and squamous cell carcinoma was observed (p value 0.001)

Conclusion: Majority of the squamous and basal cell carcinomas expressed p53 over expression with an important prognostic implication. Complete absence of p53 in malignant melanoma suggests another carcinogenic pathway not involving gene p53 mutation.

Key words:, 

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Published

2020-02-04

Issue

Volume.17, Issue-3 (Jul-Sep 2019)

Section

Original article

License

Copyright (c) 2020 Saira Javeed; Hania Naveed, Rabiya Fawad, Muhammad Kashif Baig, Ashok Kumar Tanwani, Faiz Ahmed Faiz

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How to Cite

1.
Javeed S. Overexpression and prognostic significance of p53 in Basal Cell Carcinoma, Squamous cell Carcinoma and Malignant Melanoma of the Skin. Int J Pathol [Internet]. 2020 Feb. 4 [cited 2024 Dec. 22];17(3):99-104. Available from: https://jpathology.com/index.php/OJS/article/view/468