Morphological Spectrum of Endometrial Lesions

Abstract

Introduction: Abnormal uterine bleeding is one of the commonest presentations in the gynecological clinic in
patients of all ages. Most of the cases are managed medically; endometrial biopsy is an important investigation to
diagnose the underlying cause after excluding the organic causes of abnormal uterine bleeding.
Objective: To determine the frequencies of various endometrial pathologies that are the cause of abnormal
uterine bleeding.
Methodology: A total of 485 cases of abnormal uterine bleeding were included in this cross-sectional study.
Patients with pregnancy related bleeding were excluded. The diagnosis was made on H&E sections and
frequencies were calculated by SPSS version 20.
Results: Most of the patients with abnormal uterine bleeding undergoing endometrial biopsy were in the age
range of 30-40 followed by 40-50 years age. The pathologies related to progesterone excess including estrogen
dominance, anovulatory cycles and disordered proliferative endometrium were the most common (39%)
underlying cause of abnormal uterine bleeding. 41% of patients had normal proliferative or secretory
endometrium. Inadequate samples were only 1%.
Conclusion: Endometrial biopsy is important diagnostic investigation to determine treatable causes of
endometrial pathologies.