Angiolymphoid Hyperplasia with Eosinophillia - A Rare Entity

Abstract

Objectives: To Know the frequency of angiolymphoid hyperplasia with eosinophilia.
Study Design: Cross sectional.
Material and Methods: Retrospective cases were retrieved from the files of basic Medical Science Institute, of JPMC, over
a period of 9 years (2000-2001).
Results: Only 8 cases were reported over a period of 9 years giving an average of one case every 13 months confirming the
rarity of occurrence of this lesion. Maximum cases of ALHE were seen between 21-30 year. The lesion was found more
commonly in males with 7 cases and only one female. 75% of the lesion in our study was in the head and neck region similar
to the Western studies 8.3% cases were seen in abdomen 8.3% in the back and 8.3% in the vessels. One case was seen arising
within the radial artery. In all our cases small & medium sized vessels were involved with plump endothelial cells. Cellular
component comprising of lymphocytes, histiocytes & eosinophils were seen in almost all reported cases. However lymphoid
follicle was seen in only one case.
Conclusion: It is an unusual benign vascular tumour, it is seen predominantly among Asians than in Whites, more
common in young males in second to third decades. Clinically the lesions affects the scalp, face, ears and periauricular area as
well as the neck. Peripheral blood eosinophilia and lymphadenopatly is usually associated together ALHE is marked by
proliferation of blood vessels with distinctive, large endothelial cells. These blood vessels are accompanied by characteristic
inflammatory infiltrate that includes eosinophils. Intra vascular forms of this tumour are also of note