The Frequency and Antibiotic Susceptibility Patterns of Uropathogens in a Low-Income Locality of Karachi
Keywords:
Uropathogens, antimicrobial susceptibility, multidrug resistance, low-income locality.Abstract
Objective: To assess the frequency of common organisms causing urinary tract infection and their antibiotic sensitivity patterns
in a low income locality of Karachi to guide effective empirical therapy.
Methodology: This prospective descriptive study was conducted during a period from January 2013 to December
2013 at a teaching hospital in Karachi. A total of 970 urine samples of indoor and outdoor patients were cultured
and antimicrobial sensitivity testing of all isolates were performed using commercially available disks of various
commonly used antibiotics.
Results: Our results indicated that E.coli (55.8%) was the commonest organism causing urinary tract infection in
this community. Other organisms isolated were Staphylococcus aureus, Klebsiella spp., Enterococcus spp., Serratia
spp., Enterobacter spp., Pseudomonas spp., Proteus spp., Morganella spp. and Citrobacter spp.
All organisms showed better sensitivity to imipenem followed by tazobactam and amikacin. Most species showed
resistance to multiple drugs including Augmentin, trimethoprim- sulfamethoxazole and the quinolone group of
antibiotics which are currently used as empirical therapy of UTI.
Conclusion: E.coli is the commonest uropathogen isolated. Multidrug resistance is common among uropathogens,
with high resistance against commonly used antibiotics in empirical therapy. Regular monitoring of antibiotic
resistance and concrete steps to decrease it, are needed for formulating effective empirical therapy.
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Copyright (c) 2018 Musarrat Jehan, Mahadev Harani, Rizwana Yasmin, Sahar Akhtar, Saleha Masood
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