Frequency of hypoalbuminemia in acute ischemic stroke patients presenting at Ayub teaching hospital Abbottabad

Authors

  • Zia Ul Haq Ayub Teaching Hospital Abbottabad
  • Attique Ur Rehman Jahangiri Ayub Teaching Hospital Abbottabad
  • Muhammad Hamza Ayub Teaching Hospital Abbottabad
  • Nizakat Hussain Ayub Teaching Hospital Abbottabad
  • Atiq Ullah Ayub Teaching Hospital Abbottabad
  • Qasim Shah Ayub Teaching Hospital Abbottabad

DOI:

https://doi.org/10.59736/IJP.23.04.997

Keywords:

Albumin levels, Hypoalbuminemia, Ischemic stroke,

Abstract

Background: Stroke is a condition with several contributing variables. Variations in blood albumin levels can have a significant impact on the severity, course, and outcome of the disease. The study's objective is to determine the prevalence of hypoalbuminemia in patients who arrive at Ayub Teaching Hospital, Abbottabad with acute ischemic stroke.

Methods: This Descriptive, cross-sectional study was conducted by Department of Medicine, Ayub Teaching Hospital, Abbottabad from January 2024 to June 2024.All patients who experienced an ischemic stroke between the ages of 30 and 70 were included, regardless of gender.  Patients with a history of nephrotic syndrome, transient ischemic stroke, decompensated liver disease, protein-losing enteropathy, or other chronic conditions including severe heart failure were excluded. 165 patients were selected via non-probability sequential sampling. The informed consent of each patient was sought. Serum albumin levels were determined.  Hypoalbuminemia is regarded as positive if the serum albumin level is less than 35 g/l.

Results: Mean age was 56.85 ± 11.95 years. Of the 165 patients, 72 (43.64%) were female and 93 (56.36%) were male. The average BMI was 27.60 ± 3.02 kg/m2.  60.0% had hypertension, and 62.42% had diabetes. In this study 64 patients with acute ischemic stroke (38.79%) were found to have hypoalbuminemia.

Conclusion: In light of these results, serum albumin may be a useful biomarker for acute ischemic stroke patient’s risk classification.

Author Biographies

  • Zia Ul Haq, Ayub Teaching Hospital Abbottabad

    Postgraduate Resident Physician, Ayub Teaching Hospital, Abbottabad

  • Muhammad Hamza, Ayub Teaching Hospital Abbottabad

    Postgraduate Resident Physician, Ayub Teaching Hospital, Abbottabad

  • Nizakat Hussain, Ayub Teaching Hospital Abbottabad

    Postgraduate Resident Physician, Ayub Teaching Hospital, Abbottabad

  • Atiq Ullah, Ayub Teaching Hospital Abbottabad

    Postgraduate Resident Physician, Ayub Teaching Hospital, Abbottabad

  • Qasim Shah, Ayub Teaching Hospital Abbottabad

    Postgraduate Resident Physician, Ayub Teaching Hospital, Abbottabad

References

Li J, Imano H, Yamagishi K, Cui R, Muraki I, Umesawa M et al. Serum albumin and risks of stroke and its sub types the circulatory risk in communities’ study (CIRCS). Circulation J. 2021 Mar; 85(4): 385-92. doi: 10.1253/circj. CJ-20-0384.

Bender M, Haferkorn K, Tajmiri-Gondai S, Stein M, Uhl E. Serum urea-to-albumin ratio is an independent predictor of Intra-hospital Mortality in Neurosurgical Intensive Care Unit patients with spontaneous intracerebral hemorrhage. J Clin Med. 2023 May 18; 12(10): 3538. doi: 10.3390/ jcm 12103538.

Bucci T, Pastori D, Pignatelli P, Ntaios G, Abdul-Rahim AH, Violi F et al. Albumin levels and risk of early cardiovascular complications after ischemic stroke: a propensity-matched analysis of a global federated health network. Stroke.2024 Mar; 55(3):604-12.

doi: 10.1161/STROKEAHA.123.044248.

Abraham A, Burrows S, Abraham NJ, Mandal B. Modified frailty index and hypoalbuminemia as predictors of adverse outcomes in older adults presenting to acute general surgical unit. Revista espanola de geriatric y gerontologia. 2020;55(2):70-5.

doi: 10.1016/j.regg.2019.09.005.

Gao J, Zhao Y, Du M, Guo H, Wan T, Wu M, et al. Serum albumin levels and clinical outcomes among ischemic stroke patients treated with endovascular thrombectomy. Neuropsychiatric Dise Treatment. 2021; 17:401. doi: 10.2147/NDT.S293771.

Aman H, Zakir H, Naz B, Khokar A, Manzoor W, Haque NU. Frequency of hypoalbuminemia in acute ischemic stroke patients presenting at tertiary care Hospital, Karachi. Pak J Health Sci. 2025;6(6):154-8. https://doi.org/10.54393/pjhs.v6i6.2967

Aboud HN, Mohammed HA, Kamil MM, HassanB.TheSignificanceofhypoalbumineamia and hypoproteinemia in patients with stroke. Neuroscience and Medicine. 2018;9(3):105-15.DOI: 10.4236/nm.2018.93011.

Zhou H, Wang A, Meng X, Lin J, Jiang Y, Jing J, et al. Low serum albumin levels predict poor outcome in patients with acute ischaemic stroke or transient ischaemic attack. Stroke Vasc Neurol. 2021 Feb 25;6(3):458–66. doi: 10.1136/svn-2020-000676.

Ronit A, Kirkegaard-Klitbo DM, Dohlmann TL, Lundgren J, Sabin CA, Phillips AN et al. Plasma albumin and incident cardiovascular disease: results from the CGPS and an updated meta-analysis. Arteriosclerosis, Thrombosis, Vascular Biol. 2020;40(2): 473-82.doi:10.1161/ATVBAHA.119 .313681.

Haq EH, Qayyum A, Qayyum HA, Anam M, Khan AR, Ahmed K et al. Frequency of hypoalbuminemia in acute ischemic stroke patients based on stroke severity. Pak J Med Health Sci. 2021;15(6):1335-39. DOI: https://doi.org/10.53350/pjmhs211561335

Simmons CA, Poupore N, Nathaniel TI. Age Stratification and Stroke Severity in the Telestroke Network. J Clin Med. 2023;12(4):1519. doi: 10.3390/jcm12041519.

Fantin F, Giani A, Trentin M, Rossi AP, Zoico E, Mazzali G, et al. the correlation of arterial stiffness parameters with aging and comorbidity burden. J Clin Med. 2022;11(19):5761. doi: 10.3390/jcm11195761.

Thuemmler RJ, Pana TA, Carter B, Mahmood R, Bettencourt-Silva JH, Metcalf AK, et al. Serum Albumin and Post-Stroke Outcomes: Analysis of UK Regional Registry Data, Systematic Review, and Meta-Analysis. Nutrients. 2024;16(10):1486. doi: 10.3390/nu16101486.

Yousufuddin M, Young N. Aging and ischemic stroke. Aging (Albany NY). 2019;11(9):2542-4. doi: 10.18632/aging.101931

Abubakar S, Sabir A, Ndakotsu M, Imam M, Tasiu M. Low admission serum albumin as prognostic determinant of 30-day case fatality and adverse functional outcome following acute ischemic stroke. Pan Afr Med J. 2013May;14(1). doi: 10.11604/pamj.2013.14.53.1941.

Zhang Q, Lei YX, Wang Q, Jin YP, Fu RL, Geng HH et al. Serum albumin level is associated with the recurrence of acute ischemic stroke.Am J Emergency Med. 2016;34(9):1812-6. doi:10.1016/j.ajem.2016.06.049.

James R, Antony J, Sreedhar S, Mathew R, Surendran A. Study of serum albumin as a predictor of short-term functional outcome in acute ischaemic stroke.J Evo Med Dental Sci.2017;6(36):2957-62.doi:10.14260/ Jemds/2017/637.

Elbaih AH, Elshaboury IM, Ahmed RM, Abd Allah MA. Validity and prognostic value of serum albumin level in emergency acute ischemic stroke egyptian patients. Med. 2018;7(4): 736-44.doi:10.5455 /medscience.2018.07.8844.

Shaikh F, Shaikh FH, Chandio SA. Frequency of hypoalbuminemia and in-hospital mortality in acute ischemic stroke patients presenting at a tertiary care hospital, hyderabad. Cureus. 2021;13(4): e14256. doi: 10.7759/cureus.14256.

Violi F, Novella A, Pignatelli P, Castellani V, Tettamanti M, Mannucci PM, et al. Low serum albumin is associated with mortality and arterial and venous ischemic events in acutely ill medical patients. Results of a retrospective observational study. Thrombosis Research. 2023; 225:1-10. doi: 10.1016/j.thromres.2023.02.013.

Wang Y, Zhuang Y, Huang H, Ke J, Lin S, Chen F. Association of serum albumin levels and stroke risk in adults over 40 years:Apopulationbasedstudy.Medicine(Baltimore).2023;102(36):e34848.doi:10.1097/MD.0000000000034848

Yoon CW, Bushnell CD. Stroke in Women: A Review Focused on Epidemiology, Risk Factors, and Outcomes. J Stroke. 2023;25(1):2-15. doi: 10.5853/jos.2022.03468

Alharbi AS, Alhayan MS, Alnami SK, Traad RS, Aldawsari MA, Alharbi SA et al. Epidemiology and risk factors of stroke. Archiv Pharma Prac. 2019; 10(4): 60-6. doi: 10.51847/pMfN3Q005M.

Mendelson SJ and Prabhakaran S. Diagnosis and management of transient ischemic attack and acute ischemic stroke: a review. J Am Med Assoc. 2021;325(11): 1088-98.doi: 10.1001/jama.2020.26867.

Powers WJ. Acute Ischemic Stroke. New England J Med. 2020;383(3): 252-60.doi: 10.1056/NEJMcp1917030.

EkkertA, Šliachtenko A, Grigaitė J, Burnytė B, Utkus A, Jatužis D. Ischemic stroke genetics: what is new and how to apply it in clinical practice? Genes. 2021;13(1):48. doi: 10.3390/genes13010048.

Downloads

Published

2025-12-31

Issue

Section

Original article

How to Cite

1.
Haq ZU, Jahangiri AUR, Hamza M, Hussain N, Ullah A, Shah Q. Frequency of hypoalbuminemia in acute ischemic stroke patients presenting at Ayub teaching hospital Abbottabad. Int J Pathol [Internet]. 2025 Dec. 31 [cited 2025 Dec. 31];23(4):297-304. Available from: https://jpathology.com/index.php/OJS/article/view/997

Most read articles by the same author(s)