Combined renal clear cell and papillary carcinoma with neuroendocrine dedifferentiation: a very rare entity

  • Tahmina GuL Department of Histopathology Blackrock Clinic. Dublin, Ireland
  • Kashif Siddiqui Department of urology, Hermitage Clinic Dublin, Ireland
  • Declan O Rourke Department of Pathology, Queens University Belfast
  • Mary Leader Department of Histopathology Blackrock Clinic. Dublin, Ireland

Abstract

Background: There are only few documented cases of neuroendocrine differentiation in clear cell renal cell carcinoma .

Methods: This is a case report of a combined renal clear cell and papillary carcinoma with neuroendocrine differentiation arising in an 81-year-old male.

Results: Immunohistochemistry revealed positivity for PAX8, AMACR and CD10. RCC, synaptophysin, chromogranin, WT-1, CK20, CK7, HMW CK, desmin, CD117 and PAX-2 were all negative. Immunoreactivity for NSE, CD56 and vimentin in the spindle cell component was noted. Ki-67 reactivity was variable.

Conclusion: It is suggested that immunohistochemistry for neuroendocrine differentiation should be performed in any high grade component of renal cell carcinoma (RCC) to facilitate their identification

Published
2024-01-29
How to Cite
GuL, T., Siddiqui, K., Rourke, D., & Leader, M. (2024). Combined renal clear cell and papillary carcinoma with neuroendocrine dedifferentiation: a very rare entity. International Journal of Pathology, 21(4), 153-155. Retrieved from https://jpathology.com/index.php/OJS/article/view/878