Combined renal clear cell and papillary carcinoma with neuroendocrine dedifferentiation: a very rare entity

Authors

  • Tahmina GuL Department of Histopathology Blackrock Clinic. Dublin, Ireland
  • Kashif Siddiqui Department of urology, Hermitage Clinic Dublin, Ireland
  • Declan O Rourke Department of Pathology, Queens University Belfast
  • Mary Leader Department of Histopathology Blackrock Clinic. Dublin, Ireland

Abstract

Background: There are only few documented cases of neuroendocrine differentiation in clear cell renal cell carcinoma .

Methods: This is a case report of a combined renal clear cell and papillary carcinoma with neuroendocrine differentiation arising in an 81-year-old male.

Results: Immunohistochemistry revealed positivity for PAX8, AMACR and CD10. RCC, synaptophysin, chromogranin, WT-1, CK20, CK7, HMW CK, desmin, CD117 and PAX-2 were all negative. Immunoreactivity for NSE, CD56 and vimentin in the spindle cell component was noted. Ki-67 reactivity was variable.

Conclusion: It is suggested that immunohistochemistry for neuroendocrine differentiation should be performed in any high grade component of renal cell carcinoma (RCC) to facilitate their identification

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Published

2024-01-29

Issue

Section

Case Reports

How to Cite

1.
GuL T. Combined renal clear cell and papillary carcinoma with neuroendocrine dedifferentiation: a very rare entity. Int J Pathol [Internet]. 2024 Jan. 29 [cited 2024 Jun. 20];21(4):153-5. Available from: https://jpathology.com/index.php/OJS/article/view/878