An Unusual Case of Pigmentation of Face and Hands
Keywords:
Alkaptonuria, Pigmentation, OchronosisAbstract
Alkaptonuria is a rare metabolic disorder caused by deficiency of homogentisate dioxygenase; which leads to deposition of homogentisic acid which gets deposited in connective tissue as a melanin like pigment. We had a female patient who presented to us with abnormal pigmentation on her face and hands which was not cosmetically acceptable to her. Upon exploring, she had a history of darkening of urine. Her skin biopsy demonstrated fragmented collagen and deposits of pigment in connective tissue. Subsequently she was found to have high levels of homogentisic acid in urine. We recommend that every case of abnormal hyperpigmentation should be looked for the possibility of alkaptonuria
Downloads
Published
Issue
Section
License
Copyright (c) 2018 Shawana Sharif, Anwar-Ul- Haque
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Readers may “Share-copy and redistribute the material in any medium or format” and “Adapt-remix, transform, and build upon the material”. The readers must give appropriate credit to the source of the material and indicate if changes were made to the material. Readers may not use the material for commercial purpose. The readers may not apply legal terms or technological measures that legally restrict others from doing anything the license permits.
