An Unusual Case of Pigmentation of Face and Hands

Authors

  • Shawana Sharif Department of Dermatology Benazir Bhutto Hospital, Rawalpindi Medical College, Rawalpindi
  • Anwar-Ul- Haque Department of Pathology Azad Jammu & Kashmir Medical College, Muzaffarabad, Azad Kashmir

Keywords:

Alkaptonuria, Pigmentation, Ochronosis

Abstract

Alkaptonuria is a rare metabolic disorder caused by deficiency of homogentisate dioxygenase; which leads to deposition of homogentisic acid which gets deposited in connective tissue as a melanin like pigment. We had a female patient who presented to us with abnormal pigmentation on her face and hands which was not cosmetically acceptable to her. Upon exploring, she had a history of darkening of urine. Her skin biopsy demonstrated fragmented collagen and deposits of pigment in connective tissue. Subsequently she was found to have high levels of homogentisic acid in urine. We recommend that every case of abnormal hyperpigmentation should be looked for the possibility of alkaptonuria

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Published

2018-11-21

Issue

Volume.15,Issue (January-March, 2017)

Section

Original article

License

Copyright (c) 2018 Shawana Sharif, Anwar-Ul- Haque

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

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How to Cite

1.
Sharif S, Haque A-U-. An Unusual Case of Pigmentation of Face and Hands. Int J Pathol [Internet]. 2018 Nov. 21 [cited 2024 Jul. 3];:26-30. Available from: https://jpathology.com/index.php/OJS/article/view/273