Uterine Leiomyomas: Are the Blood Vessels Main Culprit?
Keywords:
Leiomyoma, Fibroid,, Angiogenesis,, fibrosis, endothelial cell damage, extravasation of plasma.Abstract
Objective: Evaluate their histology; particularly in reference to their blood vessels and surrounding
matrix to determine the role of vascular endothelial damage in pathogenesis of leiomyomas.
Methodology: 60 cases of leiomyomas were studied by two consultant histopathologists
Place and duration of study: Combined Military Hospital & AJK Medical College, from October 2013-
December 2013
Results: All leiomyomas showed significant vascular changes. There was brisk angiogenesis, endothelial
cell damage, exudation of plasma with organization and fibrosis.
Conclusion: The vascular changes suggested hormonal effects; particularly estrogen dominance; appropriate
management of theses may retard the process of fibrosis and smooth muscle hyperplasia.
Downloads
Published
Issue
Section
License
Copyright (c) 2018 Bushra Farooq, Anwar Ul Haque
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Readers may “Share-copy and redistribute the material in any medium or format” and “Adapt-remix, transform, and build upon the material”. The readers must give appropriate credit to the source of the material and indicate if changes were made to the material. Readers may not use the material for commercial purpose. The readers may not apply legal terms or technological measures that legally restrict others from doing anything the license permits.
