The Frequency and Antibiotic Susceptibility Patterns of Uropathogens in a Low-Income Locality of Karachi

Posted on Author: .

About admin

Professor, Consultant Pathologist, American Board Certified Pathologist, Fellow College of American Pathologists. Areas of interest Fine Needle Aspiration Cytology, Cytology, Cancer, Ethics, Islam, Humanity

The Frequency and Antibiotic Susceptibility Patterns of Uropathogens in a Low-Income Locality of Karachi

Musarrat Jehan, Mahadev Harani, Rizwana Yasmin, Sahar Akhtar, Saleha Masood
Department of Pathology, Jinnah Medical & Dental College

Objective: To assess the frequency of common organisms causing urinary tract infection and their antibiotic sensitivity patterns in a low income locality of Karachi to guide effective empirical therapy.
Methodology: This prospective descriptive study was conducted during a period from January 2013 to December 2013 at a teaching hospital in Karachi. A total of 970 urine samples of indoor and outdoor patients were cultured and antimicrobial sensitivity testing of all isolates were performed using commercially available disks of various commonly used antibiotics.
Results: Our results indicated that E.coli (55.8%) was the commonest organism causing urinary tract infection in this community. Other organisms isolated were Staphylococcus aureus, Klebsiella spp., Enterococcus spp., Serratia spp., Enterobacter spp., Pseudomonas spp., Proteus spp., Morganella spp. and Citrobacter spp.
All organisms showed better sensitivity to imipenem followed by tazobactam and amikacin. Most species showed resistance to multiple drugs including Augmentin, trimethoprim- sulfamethoxazole and the quinolone group of antibiotics which are currently used as empirical therapy of UTI.
Conclusion: E.coli is the commonest uropathogen isolated. Multidrug resistance is common among uropathogens, with high resistance against commonly used antibiotics in empirical therapy. Regular monitoring of antibiotic resistance and concrete steps to decrease it, are needed for formulating effective empirical therapy.
Key words: Uropathogens, antimicrobial susceptibility, multidrug resistance, low-income locality.


 Download PDF