Post Splenectomy Septicemia in Sprague-Dawley Rats

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Professor, Consultant Pathologist, American Board Certified Pathologist, Fellow College of American Pathologists. Areas of interest Fine Needle Aspiration Cytology, Cytology, Cancer, Ethics, Islam, Humanity

Post Splenectomy Septicemia in Sprague-Dawley Rats

Anwar Ul Haque
Department of Pathology, Pakistan Institute of Medical Sciences, Islamabad.
Biological Features
Asplenia (anatomical or functional) in man is
associated with higher risk of developing certain blood
borne infections.1, 2 More remarkable, once such
infection is acquired patient rapidly goes downhill
despite aggressive treatment due to marked activation
of intravascular coagulation.3 The mortality rate is
about 50%.4 Fulminant septicemia with disseminated
intravascular coagulation (CDIC) is the hallmark of
this disease. Most of the cases have petechial
hemorrhages, massive fibrin plugs in the renal
glomeruli and bilateral adrenal hemorrhage
(Waterhouse-Friderichsen syndrome).5


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