Original Article: Physiological D-Dimer Concentration in Pregnancy

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Professor, Consultant Pathologist, American Board Certified Pathologist, Fellow College of American Pathologists. Areas of interest Fine Needle Aspiration Cytology, Cytology, Cancer, Ethics, Islam, Humanity

Original Article: Physiological D-Dimer Concentration in Pregnancy

Aliya Batool1, Samina T Amanant2, Sadaf Tariq3, Bushra Anwar4, Naghmi Asif3, Sarah Gilani5,

Zholdasbekova Ainur5, Hijab Shah4 and Amina Rasul9

1Bone marrow Transplant Unit/Department of Pathology, Islamabad Medical and Dental College/AkberNiazi Teaching Hospital, Islamabad, 2Department of Pathology, Pakistan Atomic Energy Commission Hospital, Islamabad, 3Department of Community Medicine, Islamabad Medical and Dental College, Islamabad, 4Department of Pathology, Fazaia Medical College, Islamabad, 5AkberNiazi Teaching Hospital, Islamabad, 6Watim Medical and Dental College, Islamabad


Objective: To determine the mean D-Dimer concentration in third trimester of normal pregnancy so new thresholds can be determined and applied in this population for ruling out venous thromboembolism.

Methodology: A cross sectional study conducted at the Department of Pathology, PAEC General Hospital, Islamabad.  Sample size of 127 was calculated by using WHO sample size calculator at 95% confidence interval.  Normal healthy pregnant females of third trimester attending the OPD of Gynecology and Obstetrics in PAEC were inducted in study through non-probability convenient sampling.

Results: Among 127 normal healthy pregnant females in third trimester enrolled>90% had D-Dimer concentration of more than 0.5µg/ml. (Mean value being1.0 + 0.55 µg/mL).The range of D-Dimer was 0.05 to 5.0µg/ml.Conclusion: Mean D-Dimer concentration was found to be higher in majority of cases in our study than conventional cutoff value of 0.5 µg/ml used in general population for diagnostic workup of venous thromboembolism. D-dimer test can still prove to be useful for the exclusion of thromboembolic state in pregnant women, if new cutoff baseline is defined in this special population


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