Original Article: Frequency of Autoimmune Hemolytic Anemia in Chronic Lymphocytic Leukemia

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Professor, Consultant Pathologist, American Board Certified Pathologist, Fellow College of American Pathologists. Areas of interest Fine Needle Aspiration Cytology, Cytology, Cancer, Ethics, Islam, Humanity

Original Article: Frequency of Autoimmune Hemolytic Anemia in Chronic Lymphocytic Leukemia

Saira Nasr Malik1, Komal Iqbal2, Jawad Khan3, Rashid Azeem4, Ansa Rehman5 and Shahtaj Khan6
1+4 Department of Pathology Peshawar Institute of Cardiology, Hayatabad Peshawar. 2 Department of Pathology Northwest General Hospital Hayatabad Phase-05 Peshawar. 3 Department of Gastroenterology Police services Hospital, Peshawar. 5+6 Department of Pathology Hayatabad Medical complex, Peshawar.

ABSTRACT
Introduction: Patients suffering from chronic lymphocytic leukemia (CLL) develop autoimmune complications between 5–10%, which primarily cause cytopenias. These autoimmune cytopenias can occur at various stages of CLL and do not have independent prognostic significance.
Objective: To determine the frequency of autoimmune hemolytic anemia in patients having chronic lymphocytic leukemia
Setting: Department of Hematology, Hayatabad Medical Complex, Peshawar.
Study Design: Descriptive Cross sectional study
Duration: 6 months
Material & Method: In this study, 253 patients were investigated and observed. Blood counts were performed on automated hematology analyser. Examination of Bone marrow included both bone marrow aspiration as well as trephine biopsy. Both peripheral blood smears as well as bone marrow smears was stained with Geimsa. Haematoxylin and eosin stains were used for trephine biopsies. Coomb’s test was performed on blood samples of CLL patients
Results: Mean age was 58 years in this study with SD ± 11.341. Male patients were 72% and 28% patients were female. The frequency of autoimmune hemolytic anemia was found to be 8%only.
Conclusion: Our study concludes that the frequency of autoimmune hemolytic anemia was 8% in patients suffering from chronic lymphocytic leukemia



         

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