Myelodysplastic Syndrome in Childhood

Posted on Author: .

About admin

Professor, Consultant Pathologist, American Board Certified Pathologist, Fellow College of American Pathologists. Areas of interest Fine Needle Aspiration Cytology, Cytology, Cancer, Ethics, Islam, Humanity

Myelodysplastic Syndrome in Childhood

Hina Bilal, Lubna Naseem and Nazia Siddiqui
Department of Pathology, Pakistan Institute of Medical Sciences Islamabad

Myelodysplastic syndromes (MDS) are a heterogeneous group of clonal stem cell disorders, characterized by cytopenias due to impaired blood cell production and hyper cellular and dysplastic bone marrow. The significance of MDS lies in the increased incidence of leukemic transformation. Many morphologic, immunophenotypic and genetic features observed in MDS in adults are also seen in childhood form of disease, but significant differences are reported especially in patients who do not have increased blasts in peripheral blood or bone marrow. Here we present a case of six years female, resident of Yemen, who presented to us with suspicion of aplastic anemia but later she was diagnosed as a case of MDS.
Key words: Childhood Myelodysplastic syndromes, cytopenias, dysplasia.


 Download PDF