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Iron Homeostasis: Current Understanding

Khalid Hassan and Nadeem Ikram*

Professor of Pathology, Pakistan Institute of Medical Sciences, Islamabad.

* Consultant Haematologist, DHQ Hospital, Rawalpindi.

Iron is an integral part of haemoglobin

molecule. Its deficiency leads to the commonest

type of anaemia in all geographic regions and

racial groups. Its overload, if associated with presence

of unbound iron in tissues, is characterized by tissue

injury which may be severe enough to cause

significant morbidity as a result of damage to heart,

liver, pancreas, endocrines and almost any tissue.

During the last decade, many poorly understood areas

of iron homeostasis have been unraveled, especially

pertaining to the influx of iron in the upper part of

small intestine, its trafficking in the plasma,

metabolism in the macrophage, red cell precursors &

hepatocytes, and role of genes in iron metabolism.



Post date: 2016-03-14 02:36:56
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