Iron Homeostasis: Current Understanding

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Professor, Consultant Pathologist, American Board Certified Pathologist, Fellow College of American Pathologists. Areas of interest Fine Needle Aspiration Cytology, Cytology, Cancer, Ethics, Islam, Humanity

Iron Homeostasis: Current Understanding

Khalid Hassan and Nadeem Ikram*
Professor of Pathology, Pakistan Institute of Medical Sciences, Islamabad.
* Consultant Haematologist, DHQ Hospital, Rawalpindi.
Iron is an integral part of haemoglobin
molecule. Its deficiency leads to the commonest
type of anaemia in all geographic regions and
racial groups. Its overload, if associated with presence
of unbound iron in tissues, is characterized by tissue
injury which may be severe enough to cause
significant morbidity as a result of damage to heart,
liver, pancreas, endocrines and almost any tissue.
During the last decade, many poorly understood areas
of iron homeostasis have been unraveled, especially
pertaining to the influx of iron in the upper part of
small intestine, its trafficking in the plasma,
metabolism in the macrophage, red cell precursors &
hepatocytes, and role of genes in iron metabolism.


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