FIP1L1-PDGFRA-Gene Fusion in Patients with Eosinophilia and Spinal Manifestation

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Professor, Consultant Pathologist, American Board Certified Pathologist, Fellow College of American Pathologists. Areas of interest Fine Needle Aspiration Cytology, Cytology, Cancer, Ethics, Islam, Humanity

FIP1L1-PDGFRA-Gene Fusion in Patients with Eosinophilia and Spinal Manifestation

Feroz Ali Khan1 and Qazi Muhammad Jamal2

1Demonstrator at Khyber Medical College, Peshawar, 2Casualty Medical Officer at Qazi Hussain Ahmad Medical Complex, Nowshera

ABSTRACT:

The rapid proliferation of progenitors of blood cells increases the chances of mutations and production of dysfunctional cells that often suppress the normal hematopoietic system. Chronic eosinophilic leukemia, characterized by elevated levels of pink-staining bilobed eosinophils, is one of the known pathological  presentation of unregulated proliferation of dysplastic blood cells. Tissue infiltration of heart, lungs, skin, gut and other organs has been observed previously but the formation of a mass, comprising of myeloid and eosinophilic infiltrates, around the spinal cord has rarely been seen. With the spinal mass removed, our reported patient’s eosinophilia responded to short course of imatinib however, left him bed bound due to lower limbs paralysis.



         

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