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Acute Myeloblastic Leukemia in Children

Naghmi Asif*, Khalid Hassan* and Nuzhat Yasmeen**

* Department of Pathology (Hematology Division), ** Department of Oncology Children Hospital

Pakistan Institute of Medical Sciences (PIMS), Islamabad

Background: Children constitute 15-20% of Acute Myeloid leukemia cases. Children may have different

presentations and may have different subtypes.

Objective: To study the frequency of acute myeloblastic leukemia, its subtypes and clinical manifestations in

children in a tertiary care hospital

Material & Methods: A Cross-sectional descriptive study was conducted at Department of Pathology Pakistan

Institute of Medical Sciences from July 2007- July 2009. All patients below 15 years (n 26) with diagnosis of

Acute Myeloid leukemia were included in the study. The detailed clinical history with physical findings was

entered on specially designed performa. Subtyping of AML was done on the basis of morphology and cytochemical

stains. Results were statistically analyzed through SPSS version 14.

Results: Children constituted 32% of all diagnosed cases of Most common subtype was M1 (35%) followed by M3

(31%). None of the children were diagnosed as AML-M5, M7 or M0

Conclusion: Total number of children among AML cases was 32%. Most patients presented with pallor, fever

and bleeding. Hepatosplenomegaly was more common than lymphadenopathy. The most common subtype was

AML-M1 followed by M3

Key words: acute leukemia, acute myeloblastic leukemia, childhood malignancies, clinical manifestations.



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