Bushra Farooq* and Anwar Ul Haque**
Department of Pathology *CMH ** AJK Medical College, Muzaffarabad

Abstract

Objective: Evaluate their histology; particularly in reference to their blood vessels and surrounding matrix to determine the role of vascular endothelial damage in pathogenesis of leiomyomas.
Methodology: 60 cases of leiomyomas were studied by two consultant histopathologists
Place and duration of study: Combined Military Hospital & AJK Medical College, from October 2013- December 2013
Results: All leiomyomas showed significant vascular changes. There was brisk angiogenesis, endothelial cell damage, exudation of plasma with organization and fibrosis.
Conclusion: The vascular changes suggested hormonal effects; particularly estrogen dominance; appropriate management of theses may retard the process of fibrosis and smooth muscle hyperplasia.
Key words: Leiomyoma, Fibroid, Angiogenesis, fibrosis, endothelial cell damage, extravasation of plasma.