Usefulness of Bone Marrow and Pattern of Morphological lesions in Patients of Chronic Renal Disease

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Professor, Consultant Pathologist, American Board Certified Pathologist, Fellow College of American Pathologists. Areas of interest Fine Needle Aspiration Cytology, Cytology, Cancer, Ethics, Islam, Humanity

Usefulness of Bone Marrow and Pattern of Morphological lesions in Patients of Chronic Renal Disease

Hamna Alvi*, Lubna Naseem*, Khalid Hassan**
* Department of Pathology, Pakistan Institute of Medical Sciences, Islamabad, ** Department of Pathology,
Islamabad Medical and Dental College, Islamabad

Abstract

Objective: Bone marrow examinations provide useful insight into various etiological features of altered haematology and pattern of morphological lesions in patients of Chronic Renal Disease.
Materials and Methods: A total of 58 patients with documented Chronic Renal Disease, who underwent bone marrow biopsy for various indications, were included. Their clinical data, peripheral blood and bone marrow findings were analyzed.
Results: In a total of 58 cases studied, age ranged from 15-80 years. There were 74%males and 26% females. Male to female ratio was 2.8:1. The most common among the clinical features was pallor seen in 91% of cases. Bone marrow biopsy revealed Anemia of chronic disease in 44.8%,Bone marrow hypoplasia in 37.9%, Iron deficiency in 5.1%, Multiple myeloma in 6.9%, Excessive peripheral platelet destruction in 13.7%, Chronic renal disease with known NHL and hemolysis in 1.7% of cases.
Conclusion: Bone marrow aspiration and trephine biopsies were found useful in investigating various hematological abnormalities in patients presenting with Chronic Renal Disease.
Key Words: Bone marrow biopsy, chronic renal disease.

         

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