Spectrum of Renal Stones Composition; Chemical Analysis of Renal Stones

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Professor, Consultant Pathologist, American Board Certified Pathologist, Fellow College of American Pathologists. Areas of interest Fine Needle Aspiration Cytology, Cytology, Cancer, Ethics, Islam, Humanity

Spectrum of Renal Stones Composition; Chemical Analysis of Renal Stones

Kashif Bangash*, Farwa Shigri*, Ahsan Jamal**, Khursheed Anwar*
*Pakistan Institute of Medical Sciences Islamabad, **KRL Hospital Islamabad

Background: Pakistan has probably one of the highest incidences of renal stone disease.
Objective: The study aimed to qualitatively analyze the uroliths in Pakistani population and evaluate the predominant
constituent present in them.
Materials & Methods: The study included 232 uroliths obtained by surgical intervention of Urolithiasis patients
presenting to Pakistan Institute of Medical Sciences. The stones were analyzed by DiaSys analysis kit.
Results: Males were more prone to renal stone disease (M:F is 2.7:1) and mostly affected the working age group.
All the stones contained oxalate (100%) and calcium was present in 99.5%. This was followed by uric acid (40.9%),
phosphate (25%), ammonium (7.3%), magnesium (4.3%) and cystine (0.86%).
Conclusion: Calcium Oxalate was the most predominant chemical composition in stones of 203 patients (87.5%)
followed by uric acid, struvite and calcium phosphate stones in 15 (6.5%), 10 (4.3%) and 3 (1.29%) respectively.
Key words: Uroliths, Kidney stones, Chemical composition, Calcium oxalate


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