Role of Heart Type Fatty Acid Binding Protein (HFabp) As Cardiac Bio Marker in Ischemic Heart Disease

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Role of Heart Type Fatty Acid Binding Protein (HFabp) As Cardiac Bio Marker in Ischemic Heart Disease

Imran Mehboob Baig*, Arjumand**, Abdul Shakoor Memon*, M. Asadullah***
*Department of Physiology & **Department of Pathology Basic Medical Sciences Institute, Jinnah Postgraduate
Medical Center, *** Department of Pharmacology, Hamdard College of Medicine & Dentistry
Karachi, Pakistan

Introduction: Cardiovascular diseases constitute significant morbidity and mortality worldwide. Heart-type
fatty acid binding protein (H-FABP) is a small intracellular protein which is abundant in the myocardium and
rapidly released within 1-3 hours from damaged cardiomyocytes and may be the earliest available plasma marker
of acute myocardial injury.
Material and Method: A cross sectional study was conducted at the department of physiology, BMSI, JPMC
from 2010 to 2012. During this period 60 patients suspected with Ischemic heart disease were included, out of
which 37 were male and 23 were female. Levels of cardiac markers troponin T and H-FABP were measured in the
serum of all patients and the results were compared.
Result: Total numbers of 60 individuals were included in study out of which 61.66% (37) were males and 38.33%
were females. H-FABP shows a positive result within one hour of onset of symptoms with a mean value of 22.8
ng/ml while Troponin T shows a negative result with a mean value of 0.28 ng/ml. While after 1 hour of onset of
symptoms both H-FABP and Troponin T are showing positive results by having a value >6 ng/ml and >1.5
ng/ml respectively.
Conclusion: Point-of-care assays of H-FABP in patients presenting within one hours of symptom onset may lead
to an earlier diagnosis of Ischemic Heart Disease.
Key words: Ischemic heart disease, H-FABP, Troponin T, Myocardial injury

         

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