Ambreen Moatasim, Anwar Ul Haque and Humeira Rizwan
Department of Pathology, Pakistan Institute of Medical Sciences, Islamabad.

We report here a case of a 14 year old child whose disease remained undiagnosed till death, when the diagnosis of Reye’s
syndrome was established via a core needle biopsy of liver done for academic purposes. Although Reye’s syndrome is a
diagnosis of exclusion, a high index of suspicion is critical for its diagnosis.
Key words: Reye’s syndrome, Fatty change, Micro vesicular steatosis, Needle biopsy, Autopsy.