Frequency of Autoimmune Hemolytic Anemia in Chronic Lymphocytic Leukemia

  • Saira Nasr Malik Department of Pathology Peshawar Institute of Cardiology, Hayatabad Peshawar
  • Komal Iqbal Department of Pathology Northwest General Hospital Hayatabad Phase-05 Peshawar
  • Jawad Khan Department of Gastroenterology Police services Hospital, Peshawar
  • Rashid Azeem Department of Pathology Peshawar Institute of Cardiology, Hayatabad Peshawar
  • Ansa Rehman Department of Pathology Hayatabad Medical complex, Peshawar
  • Shahtaj Khan Department of Pathology Hayatabad Medical complex, Peshawar
Keywords: Autoimmune Hemolytic Anemia, Chronic Lymphocytic Leukemia

Abstract

Introduction: Patients suffering from chronic lymphocytic leukemia (CLL) develop autoimmune complications between 5–10%, which primarily cause cytopenias. These autoimmune cytopenias can occur at various stages of CLL and do not have independent prognostic significance.

Objective: To determine the frequency of autoimmune hemolytic anemia in patients having chronic lymphocytic leukemia

Setting: Department of Hematology, Hayatabad Medical Complex, Peshawar.

Study Design: Descriptive Cross sectional study

Duration: 6 months

Material & Method: In this study, 253 patients were investigated and observed. Blood counts were performed on automated hematology analyser. Examination of Bone marrow included both bone marrow aspiration as well as trephine biopsy. Both peripheral blood smears as well as bone marrow smears was stained with Geimsa. Haematoxylin and eosin stains were used for trephine biopsies. Coomb’s test was performed on blood samples of CLL patients

Results: Mean age was 58 years in this study with SD ± 11.341. Male patients were 72% and 28% patients were female. The frequency of autoimmune hemolytic anemia was found to be 8%only.

Conclusion:  Our study concludes that the frequency of autoimmune hemolytic anemia was 8% in patients suffering from chronic lymphocytic leukemia

Published
2021-08-23