Hina Bilal, Lubna Naseem and Nazia Siddiqui
Department of Pathology, Pakistan Institute of Medical Sciences Islamabad
Myelodysplastic syndromes (MDS) are a heterogeneous group of clonal stem cell disorders, characterized by cytopenias due to impaired blood cell production and hyper cellular and dysplastic bone marrow. The significance of MDS lies in the increased incidence of leukemic transformation. Many morphologic, immunophenotypic and genetic features observed in MDS in adults are also seen in childhood form of disease, but significant differences are reported especially in patients who do not have increased blasts in peripheral blood or bone marrow. Here we present a case of six years female, resident of Yemen, who presented to us with suspicion of aplastic anemia but later she was diagnosed as a case of MDS.
Key words: Childhood Myelodysplastic syndromes, cytopenias, dysplasia.