Multidrug Resistant Escherichia coli and Klebsiella pneumoniae Causing Urinary tract Infection in Pregnant Women

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Multidrug Resistant Escherichia coli and Klebsiella pneumoniae Causing Urinary tract Infection in Pregnant Women

Naveen Qadeer*, Muhammad Asif Durrani*, Syed Manzoor Iqbal**
*Basic Medical Sciences Institute, Jinnah Postgraduate Medical College Karachi,
**Department of Pathology, Poonch Medical College, Rawlakot, Azad Kashmir

Abstract

Objective: Identify the multidrug resistant Escherichia coli and Klebsiella pneumoniae occurring in pregnant women with urinary tract infection.
Materials and Methods: A total of 200 clean catch midstream urine specimens (MSU) were collected from pregnant women in a sterile container. Specimens were then inoculated on Blood agar, MacConkey agar and cysteine lactose electrolyte deficient (CLED) agar medium. Uropathogens were identified by using battery of tests. Antimicrobial susceptibility was determined by Kirby Bauer disc diffusion method as per Clinical and Laboratory Standard Institute (CLSI) guideline.
Results: E. coli constituted 39.70% of bacterial population followed by K. pneumonia 20.58%. Antimicrobial tests, of isolated strains showed 92.68% sensitivity to imipenem, 87.8% to piperacillin/ tazobactam while 100% resistance to ampicillin.
Conclusion: E. coli remained the most common cause of UTI followed by K. pneumonia. Imepenem showed high sensitivity to UTI as compared to piperacillin/ tazobactam in our set up.
Keywords: MDR, E. coli, K. pneumoniae, UTI, pregnancy.

         

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