Kaposi Sarcoma Involving Axillary Lymph Nodes

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Professor, Consultant Pathologist, American Board Certified Pathologist, Fellow College of American Pathologists. Areas of interest Fine Needle Aspiration Cytology, Cytology, Cancer, Ethics, Islam, Humanity

Kaposi Sarcoma Involving Axillary Lymph Nodes

Ambreen Moatasim and Anwar Ul Haque
Department of Pathology, Pakistan Institute of Medical Sciences, Islamabad.
Kaposi sarcoma (KS) used to be a rare vascular sarcoma occurring in the dermis of the sole. However
with emergence of Acquired Immunodeficiency Syndrome (AIDS) not only its incidence has markedly
climbed but also other tissues are frequently involved. These include oral cavity, nose, gastrointestinal tract,
lymph nodes, lungs and liver. KS causes red or purple patches on the skin and/ or mucous membranes.
Although most patients present with skin disease, KS involvement of lymph nodes or the gastrointestinal
tract may occasionally precede the appearance of the cutaneous lesions.1
We report here a case of Kaposi sarcoma involving axillary lymph nodes without any cutaneous
lesions and with an unknown HIV status. Although there was a high index of clinical suspicion, lymph
node biopsy of the patient was the first to confirm the diagnosis of Kaposi sarcoma. Subsequently, serology
revealed that the patient was indeed HIV positive and had markedly low levels of CD4 + helper T- cells. This
case also emphasizes upon the use of oil immersion lens as a routine on histopathology sections as is this
case the diagnosis was made on 1000 magnification that clearly revealed the nuclear atypia in the
endothelial cells.


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