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Differential PTEN Protein Expression in Angiogenesis

Luoquan Wang, M.D.* and Constantine A. Axiotis, M.D.**

* Department of Pathology, Montefiore Medical Center, Bronx;

** Department of Pathology, Downstate Medical Center and the Kings County Hospital Center,


Phosphatidylinositol (PI) 3-kinase mediated

intracellular signal transduction regulates

angiogenesis. The tumor suppressor gene PTEN

product has been shown to down-regulate PI 3-kinase

signaling, suggesting possible regulatory role of PTEN

in angiogenesis. However, the expression of PTEN

protein in neovascularization in various physiological

and pathological conditions has yet to be studied. We

studied the PTEN protein expression in blood vessels

of fetal and adult tissues, reparative granulation

tissues, hemangiomas and tumor stroma. PTEN was

differentially expressed in fetal blood vessels. PTEN

immunostaining was strongly positive on fetal

capillaries and vascular wall of medium and large fetal

vessels, but was negative on endothelium of medium

and large vessels, endocardium and myocardium.

Capillaries and large vessels in chorionic villi

were positive for PTEN immunostaining. PTEN

immunostaining was negative on different-sized

adult blood vessels, weakly positive on hemangioma,

and blood vessels of granulation tissues, and weakly to

moderately positive on tumor stromal vessels. The

data suggests that PTEN participates in regulation of

angiogenesis in wide range of physiological and

pathological conditions.

Angiogenesis is



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