Salman Zafar*, Shahnaz Imdad Kehar**
Department of Pathology, Basic Medical Sciences Institute Jinnah Postgraduate Medical College Karachi
Remarkable evolutions in pathogenic role of Cyclooxygenase-2 (COX-2) in tumorigenesis have diverted
the cancer research in the direction of COX-2 inhibitors. An expanding body of evidence indicates that down
regulation of cyclooxygenase 2 will be an important strategy for preventing cancer because COX-2 catalyzes the
formation of prostaglandins(PGs) and these prostaglandins have multiple effects that favor tumorigenesis. It is
proved that during the process of chronic inflammation several cytokines and inflammatory mediators are released
which act during the different stages of carcinogenesis. Among all these mediators COX 2 are the key player. COX2
is found to be over expressed in several malignancies like colorectal carcinoma, squamous cell carcinomas of head
and neck, carcinomas of urinary bladder, liver, stomach, breast as well as hematological malignancies. Our review
article aims to summarize the role of COX 2 in various cancers and the mechanisms responsible for carcinogenesis.
The informations gathered in this review are taken mainly from articles published in different international
Key Words: COX-2 Cyclooxygenase 2.