Uzma Nabi *, Fozia Umber **, Muhammad Nafees*, Nadia Khurshid**
*Department of Pathology & ** Department of Gynecology and Obstetrictis Rashid Latif Medical College & Arif
Memorial Hospital, Lahore. Continue reading
Ashraf Mahmood, Yasir Shehzad, Soban Sarwar
Department of Neurosurgery, District Head Quarters teaching Hospital Rawalpindi
Rawalpindi Medical College, Rawalpindi Continue reading
Mahera Roohi*, Imrana Tanvir**, Sumera Qazi*
*Department of Pathology, Shalamar Medical and Dental College Lahore
**Department of Pathology, FMH College of Medicine and Dentistry Lahore
Abstract: Sarcomatoid renal cell carcinoma (SRCC) is an aggressive variant of renal cell carcinoma. It is thought
to originate predominantly from clear cell carcinoma through de-differentiation. It is a rare entity constituting about
1-5% of all renal malignant neoplasms and is more commonly associated with conventional (clear cell) renal cell
carcinomas. We report a case of 50 years old male who presented with complaints of haematuria and abdominal
pain. The biopsy confirmed sarcomatoid variant of renal cell carcinoma.
Key words: Sarcomatoid carcinoma, Renal cell carcinoma
Sarcomatoid renal cell carcinoma (SRCC) is currently defined in the 2004 World Health Organization (WHO)
classification of renal tumors as any histologic type of renal cell carcinoma (RCC) containing foci of highgrade malignant spindle cells.1 Most patients are symptomatic at diagnosis; abdominal pain and haematuria are commonly observed. Sarcomatoid tumors are characterized by a relatively high incidence of metastases to the lung and bone at
presentation.2 Positive immunohistochemical markers in these tumors include AE1/AE3, epithelial membrane antigen, and vimentin, which supports epithelial origin.3 Sarcomatoid carcinomas signify a poor prognosis.4 The prognostic implication of the proportion of sarcomatoid component within an RCC tumor is an area of controversy. A higher proportion of sarcomatoid differentiation has been associated with worse survival in some series.5
A fifty year old male presented with the history of abdominal pain and haematuria. The ultrasound and CT scan showed a renal mass. Laparotomy was performed and the nephrectomy specimen was sent for histopathology.
GROSS EXAMINATION: The whole kidney was replaced by a necrotic mass measuring 19x18x10cm.
Renal parenchyma was identified at the periphery measuring 5cm.Tumor was invading peri-nephric fat
and Gerota’s fascia.
Imran Mehboob Baig*, Arjumand**, Abdul Shakoor Memon*, M. Asadullah***
*Department of Physiology & **Department of Pathology Basic Medical Sciences Institute, Jinnah Postgraduate
Medical Center, *** Department of Pharmacology, Hamdard College of Medicine & Dentistry
Karachi, Pakistan Continue reading
*Muhammad Iqbal Khan, **Ahmed Nurus Sami and *Zyad Afzal Kiani
*Department of Surgery Azad Jammu and Kashmir Medical College Muzaffarabad Pakistan.
** Department of Surgery Islamic International Medical College Rawalpindi Pakistan Continue reading
Rifat Yasmin, Anwar ul Haq
Department of Dermatology PIMS Islamabad Continue reading
Bushra Anwar,* Khalid Hassan ** and Naghmi Asif **
*. Rawal Institute of Health Sciences
**. Islamabad Medical and Dental College, Islamabad Continue reading
Asma Khalid *, Syed Afaq Ahmed **, Anwar Ul Haque ***, Rushqia Mukhtar ****
* Department of Dermatology Islamic International medical College Rawalpindi Pakistan ** Department of
Dermatology, Pakistan Institute of Medical Sciences (PIMS) Islamabad.
***Department of Pathology Azad Jammu and Kashmir medical College Muzaffarabad Pakistan.
****Consultant Dermatologist PAEC Islamabad Continue reading
Anwar Ul Haque
Islamabad Institute of Pathology & Labs and Department of Pathology, Azad Jammu & Kashmir Medical
College, Muzaffarbad, Azad Kashmir, Pakistan Continue reading
Abhishek Singh Nayyar*, Mubeen Khan*, Pooja Gupta**
*Department Of Oral Medicine and Radiology, Government Dental College and Research Institute, Bangalore,
**Department Of Obstetrics and Gynaecology,
**Uttar Pradesh Rural Institute of Medical Sciences,
Saifai, Etawah, Uttar Pradesh, India Continue reading