Bone Marrow Transplant for Low Risk Thalassemia Patients in Low Resource Setting

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Professor, Consultant Pathologist, American Board Certified Pathologist, Fellow College of American Pathologists. Areas of interest Fine Needle Aspiration Cytology, Cytology, Cancer, Ethics, Islam, Humanity

Bone Marrow Transplant for Low Risk Thalassemia Patients in Low Resource Setting

Naila Yaqub*, Itrat Fatima, Sadaf Khalid**
* The Children’s Hospital Pakistan Institute of Medical Science, Islamabad

Abstract

Objective: To evaluate performance of a newly developed low resource Bone Marrow Transplant unit for thalassemia major in Islamabad.
Materials and Methods: Medical Records of 26 bone marrow transplants performed were revisited. Their survivals, complications, management of complications and cost of treatment were evaluated.
Results: 23 had successful engraftment with transfusion free survival. Two patients had transplant re-lated mortality. The manageable complications included hypertension and hemorrhagic cystitis. One pa-tient developed VOD.
Conclusion: Bone Marrow transplant for transfusion dependent Thalassemia is possible in low resource setup with results that are comparable with the centers in developed countries and the complications are manageable.
Key words: Bone Marrow Transplant, Thalassemia major, Low resource setup.

         

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