Jabar Ali, Muhammad Irfan, Shazeb, Adnan Mehmood Gul, Iftikhar Ahmad Khan, Mohammad Hafizullah
Department of Cardiology, Postgraduate Medical Institute, Lady Reading Hospital, Peshawar
Objectives: The objective of the study was to assess ventricular dysfunction by BNP in correlation with echocardiography
Methods: We enrolled 91 consecutive patients admitted with decompensated CHF due to CAD, RHD, COPD or non ischemic cardiomyopathy. Blood samples for BNP assay were taken and echocardiographic examination done. Data analysis was done using student’s t-test and coefficient of simple correlation using
Results: Out of 91 CCF patients 54 were male and 37 female and their mean age was 53.95±17.585 years. The presentation of patients was as; 51(56%) had CAD, 17(18.7%) RHD, 05(5.5%) COPD and 18(19.8 %) had non ischemic cardiomyopathy. Over all mean BNP level was 2019.88±1353.798 pg/ml, mean BNP level for patients with CAD was 2080.94 ± 1433.733 pg/ml, for patients with RHD it was 1811.24±1137.062 pg/ml, for patients with COPD it was 2355.00±1595.115 pg/ml, and for patients with non-ischemic cardiomyapathy it was 1950.83±1322.386 pg/ml. There was significant correlation between blood BNP levels and left ventricular end systolic diameter (r=0.208, p=0.048), left ventricular fractional shortening (r=-0.327, p=0.002), left ventricular end systolic volume (r=0.225, p=0.032), left ventricular ejection fraction (r=-0.321, p=0.002) and right ventricular end diastolic diameter (r=0.221, p=0.036). There was no significant correlation between BNP levels and left
ventricular end diastolic diameter (r=0.086, p=0.420), left atrial size (r=0.023, p=0.831). There was significant
difference in the BNP levels in the NYHA III and IV (884±685pg/ml vs. 2666±1207pg/ml, p=0.000).
Conclusions: BNP levels significantly correlate with the left ventricular size and function in systole on
echocardiography but not with the left atrial size.
Key Words: Natriuretic peptide, heart failure, echocardiography.