Acute Myeloblastic Leukemia in Children

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Professor, Consultant Pathologist, American Board Certified Pathologist, Fellow College of American Pathologists. Areas of interest Fine Needle Aspiration Cytology, Cytology, Cancer, Ethics, Islam, Humanity

Acute Myeloblastic Leukemia in Children

Naghmi Asif*, Khalid Hassan* and Nuzhat Yasmeen**
* Department of Pathology (Hematology Division), ** Department of Oncology Children Hospital
Pakistan Institute of Medical Sciences (PIMS), Islamabad

Background: Children constitute 15-20% of Acute Myeloid leukemia cases. Children may have different
presentations and may have different subtypes.
Objective: To study the frequency of acute myeloblastic leukemia, its subtypes and clinical manifestations in
children in a tertiary care hospital
Material & Methods: A Cross-sectional descriptive study was conducted at Department of Pathology Pakistan
Institute of Medical Sciences from July 2007- July 2009. All patients below 15 years (n 26) with diagnosis of
Acute Myeloid leukemia were included in the study. The detailed clinical history with physical findings was
entered on specially designed performa. Subtyping of AML was done on the basis of morphology and cytochemical
stains. Results were statistically analyzed through SPSS version 14.
Results: Children constituted 32% of all diagnosed cases of Most common subtype was M1 (35%) followed by M3
(31%). None of the children were diagnosed as AML-M5, M7 or M0
Conclusion: Total number of children among AML cases was 32%. Most patients presented with pallor, fever
and bleeding. Hepatosplenomegaly was more common than lymphadenopathy. The most common subtype was
AML-M1 followed by M3
Key words: acute leukemia, acute myeloblastic leukemia, childhood malignancies, clinical manifestations.


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