Acquired Haemophilia due to Factor-VIII Inhibitors Secondary to Bladder Malignancy: A Case Report

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Professor, Consultant Pathologist, American Board Certified Pathologist, Fellow College of American Pathologists. Areas of interest Fine Needle Aspiration Cytology, Cytology, Cancer, Ethics, Islam, Humanity

Acquired Haemophilia due to Factor-VIII Inhibitors Secondary to Bladder Malignancy: A Case Report

*Shabana Shumail, *Dr. Ayesha Junaid, **Dr. Kamran Rashid

*Hematology Department, **Oncology Department Shifa International Hospital Islamabad, Pakistan

 

Abstract: Acquired hemophilia A (AHA) is a severe bleeding diathesis caused by the appearance of autoantibodies against coagulation factor VIII (FVIII). Clinical features of inherited and acquired hemophilia are spontaneous as well as posttraumatic deep muscle-joint and mucosal bleeding. 50% cases of AHA are associated with autoimmune diseases, malignancies, medications and the postpartum period, but in the rest of the patients development of FVIII autoantibodies is idiopathic. Unexplained prolonged activated partial thromboplastin time (APTT) without previous history of bleeding should warrant work up for AHA. AHA secondary to bladder malignancy is rare with only three cases reported till to-date. We report a case of an elderly male who developed acquired hemophilia secondary to bladder malignancy and presented with a rare clinical presentation of hemarthrosis.

Key Words: Acquired hemophilia A (AHA), Factor VIII, Partial Thromboplastin Time

         

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