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A Double-Blind, Randomized Controlled Trial of Soy versus Estrogen in Alleviating Post-Menopausal Vasomotor Symptoms


Shafaq Hanif*,Mohsina Saeed Zia* and Mohsin Shakil**

* Department Gynaecology/Obstetrics, ** Department of Urology

Azad Jammu & Kashmir Medical College, Muzaffarabad, Azad Kashmir

Abstract :

Introduction: Estrogen therapy has long been prescribed to treat menopausal symptoms. It has been extensively studied, and it is the most consistently effective therapy for vasomotor symptoms. Soy has been investigated, mainly over the past 10 years, because of their potential effects on the health of postmenopausal women.

Objectives: To compare the efficacy of soy and estrogen in alleviating post-menopausal vasomotor symptom

Study Design: Randomized controlled trial.

Materials & Methods: A total of 122 post-menopausal women, 40 to 65 years of age were included. Patients on hormone replacement therapy, tamoxifen or receiving chemotherapy/radiation therapy or taking any dietary supplements were excluded. Then selected patients were placed randomly into Group A (estrogen) & Group B (soy), by using lottery method. Patients were called for follow up after 12 weeks and data was collected of the number of hot flushes average per day and efficacy.

Results: The mean age of women in group A was 52.82 ± 6.08 years and in group B was 52.09 ± 6.90 years. The mean hot flushes/day in group A was 2.56 ± 1.19 and in group B was 2.85 ± 1.25. There was 50% post-treatment reduction in hot flushes as compare to number of hot flushes average per day at pre treatment in 57 (93.44%) patients in Group A (Estrogen) while in Group B (Soy), it was seen in 46 (75.41%) patients with p-value of 0.006.
Post date: 2016-12-29 04:28:40
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Post modified date: 2016-12-29 04:28:40
Post modified date GMT: 2016-12-29 04:28:40
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